Drug name
Last update: Jul 2026Pibrentasvir (P)
Developer(s)
Drug information
Pibrentasvir
Maviret, Mavyret (when associated with Pibrentasvir)
Small molecule
DAA
Glecaprevir and Pibrentasvir (G/P) is a fixed-dose combination therapy indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1-6 with or without compensated cirrhosis. G/P consists of two pangenotypic direct-acting antiviral agents: (1) Glecaprevir which targets the HCV non-structural viral protein 3/4A (NS3/4A) serine protease, and (2) Pibrentasvir which inhibits the HCV NS5A protein - both of which are essential for viral RNA replication and viron assembly. G/P is postulated to possess advantageous pharmacological properties - including suitable target plasma exposures, half-life duration and aqueous solubility - that could potentially enable the development of a cost-effective long-acting injectable formulation via particle-processing technologies.
Glecaprevir and Pibrentasvir (G/P) oral fixed-dose combination is FDA approved
Glecaprevir and Pibrentasvir (G/P) oral fixed-dose combination is FDA approved
Therapeutic area(s)
- HCV
- Treatment
Administration route
Oral
Associated long-acting platforms
Aqueous drug particle suspension
Use of drug
- Administered by a community health worker
- Administered by a nurse
- Administered by a specialty health worker
- Self-administered
- Daily
Dosage
Not provided
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Associated compounds, formulations and regimens
Glecaprevir Pibrentasvir LA injection
Associated technologies
CompareAdditional information
Developer(s)
AbbVie
AbbVie Inc. is a global biopharmaceutical company that manufactures and develops innovative medicines as part of a diversified portfolio across several therapeutic categories including immunology, oncology, neuroscience, aesthetics and eyecare. Headquartered in North Chicago, Illinois, AbbVie was founded in 2013 following a successful corporate spin-off from its parent company Abbott Laboratories.
Drug structure
Scale-up and manufacturing prospects
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Excipients & delivery device(s)
No proprietary excipient used
No novel excipient or existing excipient used
No residual solvent used
No delivery device
Safety, Efficacy and Evidence Summary
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There are either no relevant patents or these were not yet submitted to LAPaL