Drug name
Last update: Jul 2026Paliperidone
Developer(s)
Drug information
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Paliperidone Palmitate
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Small molecule
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Paliperidone is an atypical antipsychotic drug indicated for the treatment of both schizophrenia & schizoaffective disorder. Paliperidone is the primary active metabolite of risperidone and functions by strongly binding to dopaminergic D2- and serotonergic 5-HT2-receptors and selectively blocking monoamine effects. Although paliperidone is a potent D2-antagonist, it has less of impact on motor function and catalepsy than traditional neuroleptics. Paliperidone palmitate is the palmitate ester prodrug of paliperidone and displays modest solubility in polar solvents. Several long-acting injectable aqueous nanocrystal formulations of paliperidone palmitate are available as once-monthly (PP1M), three-monthly (PP3M) and six-monthly (PP6M) extended-release suspensions for intramuscular injection.
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Therapeutic area(s)
- Mental Health Disorders (incl. schizophrenia, bipolar disorders, Schiz. Aff. Dis.)
- Treatment
Administration route
Oral, Intramuscular
Associated long-acting platforms
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Use of drug
- Administered by a nurse
- Administered by a specialty health worker
- Self-administered
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Dosage
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Associated compounds, formulations and regimens
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Associated technologies
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Developer(s)
Johnson & Johnson
Janssen Pharmaceuticals is a subsidiary company of Johnson & Johnson headquartered in Beerse, Belgium. They focus on manufacturing and developing pharmaceutical products for use in areas such as, Immunology, Infectious Diseases & Vaccines, Pulmonary Hypertension, Cardiovascular & Metabolism, Oncology, and Neuroscience.
Drug structure
Scale-up and manufacturing prospects
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Excipients & delivery device(s)
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Safety, Efficacy and Evidence Summary
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